Selected Publications

IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia. Cui TX, Brady AE, Zhang YJ, Anderson C, Popova AP. Front Immunol. 2023 Sep 8:14:1156842. DOI: 10.3389/fimmu.2023.1156842. PMID:  37744375

Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses. Cui TX, Brady AE, Zhang YJ, Fulton CT, Goldsmith AM, Popova AP. Front Immunol. 2023 Feb 10;14:1116675.  DOI: 10.3389/fimmu.2023.1116675. PMID: 36845082

Gelsolin Attenuates Neonatal Hyperoxia-Induced Inflammatory Responses to Rhinovirus Infection and Preserves Alveolarization. Cui TX, Brady AE, Zhang YJ, Fulton CT, Popova AP. Front Immunol 2022 Jan 31;13:792716. DOI: 10.3389/fimmu.2022.792716. PMID:  35173718 

Lung CD103 + dendritic cells and Clec9a signaling are required for neonatal hyperoxia-induced inflammatory responses to rhinovirus infection. Cui TX, Fulton CT, Brady AE, Zhang YJ, Goldsmith AM, Popova AP. Am J Physiol Lung Cell Mol Physiol. 2021 Feb 1;320(2):L193-L204. DOI: 10.1152/ajplung.00334.2019. PMID: 33112186 

CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia. Cui TX, Brady AE, Fulton CT, Zhang YJ, Rosenbloom LM, Goldsmith AM, Moore BB, Popova AP.  Front Immunol. 2020 Oct 6;11:579628. DOI: 10.3389/fimmu.2020.579628. PMID: 33117383 

Mesenchymal Cells and Bronchopulmonary Dysplasia: New Insights about the Dark Side of Oxygen. Popova AP. Am J Respir Cell Mol Biol. 2019 May;60(5):501-502. DOI: 10.1165/rcmb.2019-0010ED. PMID: 30768912 

Gene Expression Signatures Point to a Male Sex-Specific Lung Mesenchymal Cell PDGF Receptor Signaling Defect in Infants Developing Bronchopulmonary Dysplasia. Fulton CT, Cui TX, Goldsmith AM, Bermick J, Popova AP. Sci Rep. 2018 Nov 20;8(1):17070. DOI: 10.1038/s41598-018-35256-z. PMID: 30459472

Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages. Rajput C, Walsh MP, Eder BN, Metitiri EE, Popova AP, Hershenson MB. Physiol Genomics. 2018 May 1;50(5):299-312. PMID: 29521598

Hyperoxic Exposure of Immature Mice Increases the Inflammatory Response to Subsequent Rhinovirus Infection: Association with Danger Signals. Cui TX, Maheshwer B, Hong JY, Goldsmith AM, Bentley JK, Popova AP. J Immunol. 2016 Jun 1;196(11):4692-705. DOI: 10.4049/jimmunol.1501116. PMID: 27183577

Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia. Popova AP, Cui TX, Kaciroti N, Goldsmith AM, Linn MJ, Pryhuber GS, Hershenson MB. PLoS One. 2015 Dec 11;10(12):e0144122. PMID: 26656750

Periostin is required for maximal airways inflammation and hyperresponsiveness in mice. Bentley JK, Chen Q, Hong JY, Popova AP, Lei J, Moore BB, Hershenson MB. J Allergy Clin Immunol. 2014 Dec;134(6):1433-1442. PMID: 24996263

Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia. Popova AP, Bentley JK, Cui TX, Richardson MN, Linn MJ, Lei J, Chen Q, Goldsmith AM, Pryhuber GS, Hershenson MB. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L231-9. DOI: 10.1152/ajplung.00342.2013. PMID: 24907056

Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide. Anyanwu AC, Bentley JK, Popova AP, Malas O, Alghanem H, Goldsmith AM, Hershenson MB, Pinsky DJ. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L749-63. PMID: 24532288

Mechanisms of bronchopulmonary dysplasia. Popova AP. J Cell Commun Signal. 2013 Jun;7(2):119-27. DOI: 10.1007/s12079-013-0190-x. PMID: 23334556

Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, Carnemolla B, Orecchia P, Flaherty KR, Hershenson MB, Murray S, Martinez FJ, Moore BB; COMET Investigators. Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1046-56. PMID: 23043074

Glycogen synthase kinase-3β/β-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation. Popova AP, Bentley JK, Anyanwu AC, Richardson MN, Linn MJ, Lei J, Wong EJ, Goldsmith AM, Pryhuber GS, Hershenson MB. Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L439-48. DOI: 10.1152/ajplung.00408.2011. PMID: 22773696

Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication. Bozyk PD, Bentley JK, Popova AP, Anyanwu AC, Linn MD, Goldsmith AM, Pryhuber GS, Moore BB, Hershenson MB. PLoS One. 2012;7(2):e31336. PMID: 22363622

Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness. Schneider D, Hong JY, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley JK, Weinberg JB, Lukacs NW, Curtis JL, Sajjan US, Hershenson MB. J Immunol. 2012 Mar 15;188(6):2894-904. PMID: 22331068

Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Bozyk PD, Popova AP, Bentley JK, Goldsmith AM, Linn MJ, Weiss DJ, Hershenson MB. Stem Cells Dev. 2011 Nov;20(11):1995-2007. PMID: 21341990

Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia. Popova AP, Bozyk PD, Bentley JK, Linn MJ, Goldsmith AM, Schumacher RE, Weiner GM, Filbrun AG, Hershenson MB. Pediatrics. 2010 Nov;126(5):e1127-33. DOI: 10.1542/peds.2009-3445 PMID: 20937656

Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype. Bentley JK, Popova AP, Bozyk PD, Linn MJ, Baek AE, Lei J, Goldsmith AM, Hershenson MB. Respir Res. 2010 Sep 21;11:127. PMID: 20858250

Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. Popova AP, Bozyk PD, Goldsmith AM, Linn MJ, Lei J, Bentley JK, Hershenson MB. Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L735-43. DOI: 10.1152/ajplung.00347.2009. PMID: 20190033